CD209 CLIA Kit for Human(Homo sapiens) | EIAab.comCD209 CLIA Kit for Human(Homo sapiens) | EIAab.com

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CD209 (Gene name),

CD209 antigen (Protein name ), CD209_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

CD209(CLEC4L);

Protein name:

CD209 antigen;

Alternative:

Dendritic cell-specific ICAM-3-grabbing non-integrin 1(DC-SIGN;DC-SIGN1);C-type lectin domain family 4 member L;

CD:

CD209;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus envelope glycoproteins, cytomegalovirus gB, HCV E2 and dengue virus major envelope protein E.

Function:

On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.

Subcellular Location:

Isoform 12 Secreted

Protein Attributes:

Sequence length:

404

Sequence:

50:

MSDSKEPRLQ | QLGLLEEEQL | RGLGFRQTRG | YKSLAGCLGH | GPLVLQLLSF |

100:

TLLAGLLVQV | SKVPSSISQE | QSRQDAIYQN | LTQLKAAVGE | LSEKSKLQEI |

150:

YQELTQLKAA | VGELPEKSKL | QEIYQELTRL | KAAVGELPEK | SKLQEIYQEL |

200:

TWLKAAVGEL | PEKSKMQEIY | QELTRLKAAV | GELPEKSKQQ | EIYQELTRLK |

250:

AAVGELPEKS | KQQEIYQELT | RLKAAVGELP | EKSKQQEIYQ | ELTQLKAAVE |

300:

RLCHPCPWEW | TFFQGNCYFM | SNSQRNWHDS | ITACKEVGAQ | LVVIKSAEEQ |

350:

NFLQLQSSRS | NRFTWMGLSD | LNQEGTWQWV | DGSPLLPSFK | QYWNRGEPNN |

400:

VGEEDCAEFS | GNGWNDDKCN | LAKFWICKKS | AASCSRDEEQ | FLSPAPATPN |

404:

PPPA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

String:

Pfam:

SMR:

KEGG:

UniGene:

Uniprot:

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ELISA Kit for Human CD209 antigen

Cat.:

E1846h

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human CD209 antigen

Cat.:

U1846h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human CD209 antigen

Cat.:

P1846Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human CD209 antigen

Protein for Human CD209 antigen

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp 120."
Curtis B.M. , Scharnowske S. , Watson A.J.
Proc. Natl. Acad. Sci. U.S.A.89:8356-8360(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;INTERACTION WITH HIV-1 GP120
tissue: Placenta.
2.

"DC-SIGN, a related gene, DC-SIGNR, and CD23 form a cluster on 19p13."
Soilleux E.J. , Barten R. , Trowsdale J.
J. Immunol.165:2937-2942(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
3.

"A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection."
Bashirova A.A. , Geijtenbeek T.B.H. , van Duijnhoven G.C.F. , van Vliet S.J. , Eilering J.B.G. , Martin M.P. , Wu L. , Martin T.D. , Viebig N. , Knolle P.A. , Kewalramani V.N. , van Kooyk Y. , Carrington M.
J. Exp. Med.193:671-678(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
4.

"Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts."
Mummidi S. , Catano G. , Lam L. , Hoefle A. , Telles V. , Begum K. , Jimenez F. , Ahuja S.S. , Ahuja S.K.
J. Biol. Chem.276:33196-33212(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11 AND 12);ALTERNATIVE SPLICING;TISSUE SPECIFICITY
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Uterus.
6.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10)
9.

"DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells."
Geijtenbeek T.B.H. , Kwon D.S. , Torensma R. , van Vliet S.J. , van Duijnhoven G.C.F. , Middel J. , Cornelissen I.L. , Nottet H.S. , Kewalramani V.N. , Littman D.R. , Figdor C.G. , van Kooyk Y.
Cell100:587-597(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ICAM3
10.

"DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking."
Geijtenbeek T.B.H. , Krooshoop D.J. , Bleijs D.A. , van Vliet S.J. , van Duijnhoven G.C.F. , Grabovsky V. , Alon R. , Figdor C.G. , van Kooyk Y.
Nat. Immunol.1:353-357(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ICAM2
11.

"A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands."
Mitchell D.A. , Fadden A.J. , Drickamer K.
J. Biol. Chem.276:28939-28945(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;LIGAND-BINDING
12.

"Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection."
Halary F. , Amara A. , Lortat-Jacob H. , Messerle M. , Delaunay T. , Houles C. , Fieschi F. , Arenzana-Seisdedos F. , Moreau J.-F. , Dechanet-Merville J.
Immunity17:653-664(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CYTOMEGALOVIRUS GLYCOPROTEIN B (GB)
13.

"Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1."
Geijtenbeek T.B.H. , van Duijnhoven G.C.F. , van Vliet S.J. , Krieger E. , Vriend G. , Figdor C.G. , van Kooyk Y.
J. Biol. Chem.277:11314-11320(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ICAM 3 AND HIV-1 GP120;MUTAGENESIS OF ASP-320; GLU-324; GLU-347; ASN-349; ASN-350; ASP-355; ASN-365 AND ASP-366
14.

"The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells."
Engering A. , Geijtenbeek T.B.H. , van Vliet S.J. , Wijers M. , van Liempt E. , Demaurex N. , Lanzavecchia A. , Fransen J. , Figdor C.G. , Piguet V. , van Kooyk Y.
J. Immunol.168:2118-2126(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF 14-LEU-LEU-15
15.

"DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection."
Kwon D.S. , Gregorio G. , Bitton N. , Hendrickson W.A. , Littman D.R.
Immunity16:135-144(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN HIV-1 INFECTION
16.

"Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR."
Lin G. , Simmons G. , Poehlmann S. , Baribaud F. , Ni H. , Leslie G.J. , Haggarty B.S. , Bates P. , Weissman D. , Hoxie J.A. , Doms R.W.
J. Virol.77:1337-1346(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 GP120; HIV-2 GP120; SIV GP120 AND EBOLA GLYCOPROTEINS
17.

"Inhibition of human immunodeficiency virus type 1 Env-mediated fusion by DC-SIGN."
Nobile C. , Moris A. , Porrot F. , Sol-Foulon N. , Schwartz O.
J. Virol.77:5313-5323(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HIV-1 INFECTION
18.

"Carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells."
Appelmelk B.J. , van Die I. , van Vliet S.J. , Vandenbroucke-Grauls C.M. , Geijtenbeek T.B.H. , van Kooyk Y.
J. Immunol.170:1635-1639(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"DC-SIGN: escape mechanism for pathogens."
van Kooyk Y. , Geijtenbeek T.B.H.
Nat. Rev. Immunol.3:697-709(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN HIV-1 INFECTION AND ON PATHOGEN BINDING
20.

"The role of dendritic cell C-type lectin receptors in HIV pathogenesis."
Turville S. , Wilkinson J. , Cameron P. , Dable J. , Cunningham A.L.
J. Leukoc. Biol.74:710-718(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN HIV-1 INFECTION
21.

"L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus."
Cormier E.G. , Durso R.J. , Tsamis F. , Boussemart L. , Manix C. , Olson W.C. , Gardner J.P. , Dragic T.
Proc. Natl. Acad. Sci. U.S.A.101:14067-14072(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCV E2 GLYCOPROTEIN
22.

"A variant in the CD209 promoter is associated with severity of dengue disease."
Sakuntabhai A. , Turbpaiboon C. , Casademont I. , Chuansumrit A. , Lowhnoo T. , Kajaste-Rudnitski A. , Kalayanarooj S.M. , Tangnararatchakit K. , Tangthawornchaikul N. , Vasanawathana S. , Chaiyaratana W. , Yenchitsomanus P.T. , Suriyaphol P. , Avirutnan P. , Chokephaibulkit K. , Matsuda F. , Yoksan S. , Jacob Y. , more...
Nat. Genet.37:507-513(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN SUSCEPTIBILITY TO DENGUE VIRUS INFECTION
23.

"DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells."
Hosszu K.K. , Valentino A. , Vinayagasundaram U. , Vinayagasundaram R. , Joyce M.G. , Ji Y. , Peerschke E.I. , Ghebrehiwet B.
Blood120:1228-1236(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C1QBP
24.

"Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR."
Feinberg H. , Mitchell D.A. , Drickamer K. , Weis W.I.
Science294:2163-2166(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 254-382 IN COMPLEX WITH GLCNAC(2)-MAN(3) PENTASACCHARIDE
25.

"Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis."
Barreiro L.B. , Neyrolles O. , Babb C.L. , Tailleux L. , Quach H. , McElreavey K. , Helden P.D. , Hoal E.G. , Gicquel B. , Quintana-Murci L.
PLoS Med.3:230-235(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MYCOBACTERIUM TUBERCULOSIS SUSCEPTIBILITY

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